YKU80
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PIF1
Gene Ontology Biological Process
- DNA recombination [IMP]
- DNA strand renaturation [IDA]
- G-quadruplex DNA unwinding [IMP]
- chromosome organization [IMP]
- double-strand break repair via break-induced replication [IMP]
- mitochondrial genome maintenance [IMP]
- negative regulation of telomere maintenance via telomerase [IDA, IMP]
- telomere maintenance [IMP]
- telomere maintenance via recombination [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae.
Gross chromosome rearrangements (GCRs), such as translocations, deletion of a chromosome arm, interstitial deletions and inversions, are often observed in cancer cells. Spontaneous GCRs are rare in Saccharomyces cerevisiae; however, the existence of mutator mutants with increased genome instability suggests that GCRs are actively suppressed. Here we show by genetic analysis that these genome rearrangements probably result from DNA replication ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: chromosome/plasmid maintenance (APO:0000143)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
YKU80 PIF1 | Dosage Growth Defect Dosage Growth Defect A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 447983 | |
YKU80 PIF1 | Dosage Lethality Dosage Lethality A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 213338 | |
PIF1 YKU80 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 3310770 |
Curated By
- BioGRID