BAIT

STO1

CBC1, CBP80, GCR3, SUT1, L000002131, YMR125W

Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80

GO Process (3)

GO Function (1)

GO Component (4)

Gene Ontology Biological Process

mRNA splicing, via spliceosome [IPI]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IDA, IPI]

response to osmotic stress [IMP]

Gene Ontology Molecular Function

mRNA binding [IDA, IPI]

Gene Ontology Cellular Component

commitment complex [IPI]

nuclear cap binding complex [IDA]

nucleus [IDA]

polysome [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

PREY

GCR1

LPF10, SIT3, transcription regulator GCR1, L000000690, S000029447, L000001900, YPL075W

Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p

GO Process (6)

GO Function (2)

GO Component (1)

Gene Ontology Biological Process

negative regulation of transcription from RNA polymerase II promoter by glucose [IMP]

nucleosome organization [IMP]

positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter [IMP]

positive regulation of transcription from RNA polymerase II promoter [IMP]

positive regulation of transcription from a mobile element promoter [IMP]

regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter [IMP]

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, IMP]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]

Gene Ontology Cellular Component

nuclear envelope [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Genetic and physical interactions involving the yeast nuclear cap-binding complex.

Fortes P, Kufel J, Fornerod M, Polycarpou-Schwarz M, Lafontaine D, Tollervey D, Mattaj IW

Yeast strains lacking the yeast nuclear cap-binding complex (yCBC) are viable, although impaired in growth. We have taken advantage of this observation to carry out a genetic screen for components that show synthetic lethality (SL) with a cbp20-Delta cbp80-Delta double mutation. One set of SL interactions was due to mutations that were complemented by components of U1 small nuclear RNP ... [more]

Mol. Cell. Biol. Oct. 01, 1999; 19(10);6543-53 [Pubmed: 10490594]

Throughput

High Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Additional Notes

in cbp20 background

Curated By

BioGRID

Interaction Summary

STO1

Gene Ontology Biological Process

Gene Ontology Molecular Function

mRNA binding [IDA, IPI]

Gene Ontology Cellular Component

GCR1

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, IMP]RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]

Gene Ontology Cellular Component

Synthetic Lethality

Publication

Genetic and physical interactions involving the yeast nuclear cap-binding complex.

Throughput

Ontology Terms

Additional Notes

Curated By

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, IMP]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]