GCN5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SWI1
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IDA]
- DNA-dependent DNA replication [IMP]
- carbon catabolite activation of transcription from RNA polymerase II promoter [IGI]
- cellular alcohol catabolic process [IMP]
- positive regulation of mating type switching [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation [IMP]
- sucrose catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SWI/SNF complex [IDA, IMP]
- nucleus [IDA]
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Role for ADA/GCN5 products in antagonizing chromatin-mediated transcriptional repression.
The Saccharomyces cerevisiae SWI/SNF complex is a 2-MDa multimeric assembly that facilitates transcriptional enhancement by antagonizing chromatin-mediated transcriptional repression. We show here that mutations in ADA2, ADA3, and GCN5, which are believed to encode subunits of a nuclear histone acetyltransferase complex, cause phenotypes strikingly similar to that of swi/snf mutants. ADA2, ADA3, and GCN5 are required for full expression of ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
GCN5 SWI1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
GCN5 SWI1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 163641 |
Curated By
- BioGRID