BAIT
PDR17
ISS1, SFH4, L000004780, YNL264C
Phosphatidylinositol transfer protein (PITP); downregulates Plb1p-mediated turnover of phosphatidylcholine; forms a complex with Psd2p which appears essential for maintenance of vacuolar PE levels; found in the cytosol and microsomes; homologous to Pdr16p; deletion affects phospholipid composition
GO Process (8)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [IGI]
- negative regulation of phosphatidylglycerol biosynthetic process [IGI]
- phosphatidylserine metabolic process [IMP]
- phospholipid biosynthetic process [IGI]
- phospholipid transport [IDA, IGI, IMP]
- positive regulation of phosphatidylcholine biosynthetic process [IGI]
- response to drug [IGI]
- sterol biosynthetic process [IGI]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
BET1
SLY12, L000000171, YIL004C
Type II membrane protein required for vesicular transport; required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins
GO Process (3)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Sec24p and Iss1p function interchangeably in transport vesicle formation from the endoplasmic reticulum in Saccharomyces cerevisiae.
The Sec23p/Sec24p complex functions as a component of the COPII coat in vesicle transport from the endoplasmic reticulum. Here we characterize Saccharomyces cerevisiae SEC24, which encodes a protein of 926 amino acids (YIL109C), and a close homologue, ISS1 (YNL049C), which is 55% identical to SEC24. SEC24 is essential for vesicular transport in vivo because depletion of Sec24p is lethal, causing ... [more]
Mol. Biol. Cell Mar. 01, 2000; 11(3);983-98 [Pubmed: 10712514]
Throughput
- Low Throughput
Ontology Terms
- inviable (APO:0000112)
Curated By
- BioGRID