BAIT
MPS3
NEP98, YJL018W, YJL019W
Nuclear envelope protein; required for SPB insertion, SPB duplication, Kar5p localization near the SPB and nuclear fusion; interacts with Mps2p to tether half-bridge to core SPB; N-terminal acetylation by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; member of the SUN protein family (Sad1-UNC-84 homology)
GO Process (9)
GO Function (0)
GO Component (6)
Gene Ontology Biological Process
- chromatin silencing at telomere [IMP]
- establishment of mitotic sister chromatid cohesion [IMP]
- karyogamy [IMP]
- meiotic telomere clustering [IGI, IMP]
- mitotic sister chromatid cohesion [IMP]
- nuclear migration involved in conjugation with cellular fusion [IMP]
- spindle pole body duplication [IMP]
- synapsis [IGI, IMP]
- telomere tethering at nuclear periphery [IMP]
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
CMD1
calmodulin, CaM, L000000365, YBR109C
Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
GO Process (10)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [IMP]
- cell budding [IMP]
- cytoskeleton organization [IMP]
- karyogamy involved in conjugation with cellular fusion [IGI, IMP]
- microautophagy [IMP]
- phosphatidylinositol biosynthetic process [IGI, IMP]
- receptor-mediated endocytosis [IMP]
- spindle pole body organization [IMP]
- transcription factor import into nucleus [IMP]
- vacuole fusion, non-autophagic [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p.
Accurate duplication of the Saccharomyces cerevisiae spindle pole body (SPB) is required for formation of a bipolar mitotic spindle. We identified mutants in SPB assembly by screening a temperature-sensitive collection of yeast for defects in SPB incorporation of a fluorescently marked integral SPB component, Spc42p. One SPB assembly mutant contained a mutation in a previously uncharacterized open reading frame that ... [more]
J. Cell Biol. Dec. 23, 2002; 159(6);945-56 [Pubmed: 12486115]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID