BAIT
DST1
PPR2, SII, S-II, TFIIS, P37, L000001476, L000000530, YGL043W
General transcription elongation factor TFIIS; enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress
GO Process (11)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- mRNA cleavage [IDA, IMP]
- maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter [IGI, IMP]
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [IDA, IMP]
- positive regulation of transcription elongation from RNA polymerase II promoter [IDA]
- regulation of mRNA 3'-end processing [IGI, IMP]
- tRNA transcription from RNA polymerase III promoter [IMP]
- transcription antitermination [IDA]
- transcription elongation from RNA polymerase I promoter [IDA]
- transcription elongation from RNA polymerase II promoter [IDA, IMP]
- transcription from RNA polymerase III promoter [IDA]
- transcription initiation from RNA polymerase II promoter [IDA, IGI, IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
KEX2
QDS1, SRB1, VMA45, kexin KEX2, yscF, L000000896, YNL238W
Kexin, a subtilisin-like protease (proprotein convertase); a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway
GO Process (1)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Genetic interactions between TFIIS and the Swi-Snf chromatin-remodeling complex.
The eukaryotic transcript elongation factor TFIIS enables RNA polymerase II to read through blocks to elongation in vitro and interacts genetically with a variety of components of the transcription machinery in vivo. In Saccharomyces cerevisiae, the gene encoding TFIIS (PPR2) is not essential, and disruption strains exhibit only mild phenotypes and an increased sensitivity to 6-azauracil. The nonessential nature of ... [more]
Mol. Cell. Biol. Aug. 01, 2000; 20(16);5960-73 [Pubmed: 10913179]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID