RGD1
Gene Ontology Biological Process
Gene Ontology Molecular Function- Rho GTPase activator activity [IDA, IGI]
- phosphatidylinositol-3,5-bisphosphate binding [IDA, IMP]
- phosphatidylinositol-3-phosphate binding [IDA, IMP]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA, IMP]
- phosphatidylinositol-5-phosphate binding [IDA, IMP]
- Rho GTPase activator activity [IDA, IGI]
- phosphatidylinositol-3,5-bisphosphate binding [IDA, IMP]
- phosphatidylinositol-3-phosphate binding [IDA, IMP]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA, IMP]
- phosphatidylinositol-5-phosphate binding [IDA, IMP]
Gene Ontology Cellular Component
LAS17
Gene Ontology Biological Process
Gene Ontology Molecular Function- actin binding [IDA, IPI]
- actin binding [IDA, IPI]
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Evidence for the genetic interaction between the actin-binding protein Vrp1 and the RhoGAP Rgd1 mediated through Rho3p and Rho4p in Saccharomyces cerevisiae.
The non-essential RGD1 gene from Saccharomyces cerevisiae encodes a protein that has been characterized in vitro as a Rho GTPase activating protein (RhoGAP) for the Rho3 and Rho4 proteins. Rgd1p, which displays a conserved FCH-coiled coil-Rho-GAP domain organization, showed a patch-like distribution in the cell, including a localization in growing buds. Using a genetic screen, we found that rgd1delta and ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RGD1 LAS17 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 158653 | |
| LAS17 RGD1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID