SPT5
Gene Ontology Biological Process
- 7-methylguanosine mRNA capping [IGI, IPI]
- intracellular mRNA localization [IMP]
- mRNA splicing, via spliceosome [IMP]
- negative regulation of transcription elongation from RNA polymerase I promoter [IGI]
- positive regulation of transcription elongation from RNA polymerase I promoter [IMP]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- regulation of rRNA processing [IMP]
- regulation of transcription-coupled nucleotide-excision repair [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SPT6
Gene Ontology Biological Process
- chromatin maintenance [IMP]
- chromatin organization involved in regulation of transcription [IGI, IMP]
- chromatin remodeling [IGI, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter by glucose [IMP]
- nucleosome assembly [IDA]
- nucleosome organization [IMP]
- poly(A)+ mRNA export from nucleus [IMP]
- positive regulation of transcription elongation from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
- regulation of histone H3-K36 methylation [IDA, IMP]
- regulation of mRNA 3'-end processing [IGI, IMP]
- regulation of nucleosome density [IMP]
- regulation of transcription from RNA polymerase II promoter in response to stress [IMP]
- regulation of transcriptional start site selection at RNA polymerase II promoter [IMP]
- transcription antitermination [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
SPT4, SPT5 and SPT6 interactions: effects on transcription and viability in Saccharomyces cerevisiae.
The SPT4, SPT5 and SPT6 genes of Saccharomyces cerevisiae were identified originally by mutations that suppress delta insertion mutations at HIS4 and LYS2. Subsequent analysis has demonstrated that spt4, spt5 and spt6 mutations confer similar pleiotropic phenotypes. They suppress delta insertion mutations by altering transcription and are believed to be required for normal transcription of several other loci. We have ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SPT5 SPT6 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| SPT5 SPT6 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| SPT6 SPT5 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| SPT6 SPT5 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 6 | BioGRID | 3596653 | |
| SPT5 SPT6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| SPT6 SPT5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| SPT5 SPT6 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 3308785 | |
| SPT6 SPT5 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | High | - | BioGRID | 3312433 |
Curated By
- BioGRID