BAIT

VRP1

END5, MDP2, YLR337W, L000001055, L000002481, YLR337C
Verprolin, proline-rich actin-associated protein; involved in cytoskeletal organization and cytokinesis; promotes actin nucleation and endocytosis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)
Saccharomyces cerevisiae (S288c)
PREY

RGD1

YBR260C
GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; possibly involved in control of actin cytoskeleton organization
Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Evidence for the genetic interaction between the actin-binding protein Vrp1 and the RhoGAP Rgd1 mediated through Rho3p and Rho4p in Saccharomyces cerevisiae.

Roumanie O, Peypouquet MF, Bonneu M, Thoraval D, Doignon F, Crouzet M

The non-essential RGD1 gene from Saccharomyces cerevisiae encodes a protein that has been characterized in vitro as a Rho GTPase activating protein (RhoGAP) for the Rho3 and Rho4 proteins. Rgd1p, which displays a conserved FCH-coiled coil-Rho-GAP domain organization, showed a patch-like distribution in the cell, including a localization in growing buds. Using a genetic screen, we found that rgd1delta and ... [more]

Mol. Microbiol. Jun. 01, 2000; 36(6);1403-14 [Pubmed: 10931290]

Throughput

  • Low Throughput

Ontology Terms

  • actin cytoskeleton morphology (APO:0000120)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
RGD1 VRP1
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
158655

Curated By

  • BioGRID