BAIT

STE4

HMD2, L000002114, YOR212W
G protein beta subunit; forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats
Saccharomyces cerevisiae (S288c)
PREY

SST2

GTPase-activating protein SST2, L000002093, YLR452C
GTPase-activating protein for Gpa1p; regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
GO Process (2)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Saccharomyces cerevisiae mutants unresponsive to alpha-factor pheromone: alpha-factor binding and extragenic suppression.

Jenness DD, Goldman BS, Hartwell LH

Mutations in six genes that eliminate responsiveness of Saccharomyces cerevisiae a cells to alpha-factor were examined by assaying the binding of radioactively labeled alpha-factor to determine whether their lack of responsiveness was due to the absence of alpha-factor receptors. The ste2 mutants, known to be defective in the structural gene for the receptor, were found to lack receptors when grown ... [more]

Mol. Cell. Biol. Apr. 01, 1987; 7(4);1311-9 [Pubmed: 3037311]

Throughput

  • Low Throughput

Ontology Terms

  • mating efficiency (APO:0000034)
  • sterile (APO:0000045)

Additional Notes

  • in either ros1 ros2 ros3 background

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
STE4 SST2
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
161645

Curated By

  • BioGRID