BUD8
Gene Ontology Biological Process
Gene Ontology Cellular Component
RAS2
Gene Ontology Biological Process
- activation of adenylate cyclase activity [IDA]
- ascospore formation [IMP]
- positive regulation of adenylate cyclase activity [IGI]
- positive regulation of pseudohyphal growth [IMP]
- positive regulation of transcription by galactose [IMP]
- protein localization to bud neck [IGI]
- regulation of protein localization [IMP]
- replicative cell aging [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Dissection of filamentous growth by transposon mutagenesis in Saccharomyces cerevisiae.
Diploid Saccharomyces cerevisiae strains starved for nitrogen undergo a developmental transition from growth as single yeast form (YF) cells to a multicellular form consisting of filaments of pseudohyphal (PH) cells. Filamentous growth is regulated by an evolutionarily conserved signaling pathway that includes the small GTP-binding proteins Ras2p and Cdc42p, the protein kinases Ste20p, Ste11p and Ste7p, and the transcription factor ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cell shape (APO:0000051)
Additional Notes
- Overexpression of the hit protein allows pseudohyphal growth which is blocked in the single mutant
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
RAS2 BUD8 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2336 | BioGRID | 2169465 |
Curated By
- BioGRID