BAIT
BDF1
chromatin-binding protein BDF1, L000000165, YLR399C
Protein involved in transcription initiation; functions at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p; BDF1 has a paralog, BDF2, that arose from the whole genome duplication
GO Process (8)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- DNA repair [IMP]
- chromatin organization involved in regulation of transcription [IMP]
- chromatin remodeling [IPI]
- negative regulation of heterochromatin assembly [IGI, IMP]
- positive regulation of histone exchange [IMP]
- regulation of chromatin silencing at silent mating-type cassette [IMP]
- regulation of chromatin silencing at telomere [IMP]
- snRNA transcription [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
HFI1
ADA1, GAN1, SRM12, SUP110, L000003094, YPL254W
Adaptor protein required for structural integrity of the SAGA complex; a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Different sensitivities of bromodomain factors 1 and 2 to histone H4 acetylation.
The histone code hypothesis proposes that covalently modified histone tails are binding sites for specific proteins. In vitro evidence suggests that factors containing bromodomains read the code by binding acetylated histone tails. Bromodomain Factor 1 (Bdf1), a protein that associates with TFIID, binds histone H4 with preference for multiply acetylated forms. In contrast, the closely related protein Bdf2 shows no ... [more]
Mol. Cell Feb. 01, 2003; 11(2);353-63 [Pubmed: 12620224]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID