MCD1
Gene Ontology Biological Process
- DNA unwinding involved in DNA replication [IMP]
- apoptotic process [IMP]
- cellular response to DNA damage stimulus [IMP]
- double-strand break repair [IMP]
- establishment of mitotic sister chromatid cohesion [IMP]
- mitotic chromosome condensation [IMP]
- replication-born double-strand break repair via sister chromatid exchange [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
YCG1
Gene Ontology Biological Process
- meiotic chromosome condensation [IMP]
- meiotic chromosome separation [IMP]
- mitotic chromosome condensation [IGI, IMP]
- mitotic sister chromatid segregation [IMP]
- negative regulation of meiotic DNA double-strand break formation [IMP]
- rDNA condensation [IMP]
- synaptonemal complex assembly [IMP]
- tRNA gene clustering [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
In vivo dissection of the chromosome condensation machinery: reversibility of condensation distinguishes contributions of condensin and cohesin.
The machinery mediating chromosome condensation is poorly understood. To begin to dissect the in vivo function(s) of individual components, we monitored mitotic chromosome structure in mutants of condensin, cohesin, histone H3, and topoisomerase II (topo II). In budding yeast, both condensation establishment and maintenance require all of the condensin subunits, but not topo II activity or phospho-histone H3. Structural maintenance ... [more]
Throughput
- Low Throughput
Ontology Terms
- chromosome/plasmid maintenance (APO:0000143)
Additional Notes
- mutation of Ycg1 allows for reversal of chromosome condensation defects seen in an Mcd1 mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MCD1 YCG1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1686 | BioGRID | 1922637 |
Curated By
- BioGRID