BAIT
PGM2
GAL5, phosphoglucomutase PGM2, L000001413, YMR105C
Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress; PGM2 has a paralog, PGM1, that arose from the whole genome duplication
GO Process (8)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- UDP-glucose metabolic process [IGI]
- cellular calcium ion homeostasis [IGI, IMP]
- cellular cation homeostasis [IMP]
- galactose catabolic process [IGI, IMP]
- glucose 1-phosphate metabolic process [IGI, IMP, ISS]
- glucose 6-phosphate metabolic process [ISS]
- glycogen biosynthetic process [IGI]
- trehalose biosynthetic process [IGI]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
TPS1
BYP1, CIF1, FDP1, GGS1, GLC6, TSS1, alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1, L000002330, YBR126C
Synthase subunit of trehalose-6-P synthase/phosphatase complex; synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Dosage Lethality
A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.
Publication
The trehalose pathway and intracellular glucose phosphates as modulators of potassium transport and general cation homeostasis in yeast.
Trk, encoded by the partially redundant genes TRK1 and TRK2, is the major potassium transporter of Saccharomyces cerevisiae. This system is specific for potassium and rubidium but, by reducing the electrical membrane potential of the plasma membrane, Trk decreases the uptake of toxic cations such as lithium, calcium, aminoglycosides and polyamines, which are transported by other systems. Gain- and loss-of-function ... [more]
Yeast May. 01, 2004; 21(7);569-82 [Pubmed: 15164360]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID