BAIT
CHD1
chromatin-remodeling ATPase CHD1, L000003467, YER164W
Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes
GO Process (14)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IDA]
- chromatin organization involved in regulation of transcription [IGI, IMP]
- histone H2B conserved C-terminal lysine ubiquitination [IMP]
- negative regulation of DNA-dependent DNA replication [IGI]
- negative regulation of histone H3-K14 acetylation [IMP]
- negative regulation of histone H3-K9 acetylation [IMP]
- negative regulation of histone exchange [IMP]
- nucleosome mobilization [IDA]
- nucleosome positioning [IDA, IGI]
- regulation of chromatin organization [IMP]
- regulation of transcriptional start site selection at RNA polymerase II promoter [IGI]
- termination of RNA polymerase I transcription [IGI]
- termination of RNA polymerase II transcription [IGI, IMP]
- transcription elongation from RNA polymerase II promoter [IGI, IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
SNF2
GAM1, HAF1, SWI2, TYE3, SWI/SNF catalytic subunit SNF2, L000001945, YOR290C
Catalytic subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
GO Process (13)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IDA, IMP]
- DNA-dependent DNA replication [IMP]
- cellular alcohol catabolic process [IMP]
- chromatin remodeling [IGI, IMP]
- double-strand break repair [IMP]
- nucleosome mobilization [IDA, IMP]
- positive regulation of cell adhesion involved in single-species biofilm formation [IMP]
- positive regulation of invasive growth in response to glucose limitation [IMP]
- positive regulation of mating type switching [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation [IMP]
- strand invasion [IMP]
- sucrose catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SWI/SNF complex [IDA, IMP]
- nucleus [IDA]
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The chromo domain protein chd1p from budding yeast is an ATP-dependent chromatin-modifying factor.
CHD proteins are members of the chromo domain family, a class of proteins involved in transcription, DNA degradation and chromatin structure. In higher eukaryotes, there are two distinct subfamilies of CHD proteins: CHD1 and CHD3/4. Analyses carried out in vitro indicate that the CHD3/4 proteins may regulate transcription via alteration of chromatin structure. However, little is known about the role ... [more]
EMBO J. May. 15, 2000; 19(10);2323-31 [Pubmed: 10811623]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID