SNF2
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IDA, IMP]
- DNA-dependent DNA replication [IMP]
- cellular alcohol catabolic process [IMP]
- chromatin remodeling [IGI, IMP]
- double-strand break repair [IMP]
- nucleosome mobilization [IDA, IMP]
- positive regulation of cell adhesion involved in single-species biofilm formation [IMP]
- positive regulation of invasive growth in response to glucose limitation [IMP]
- positive regulation of mating type switching [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation [IMP]
- strand invasion [IMP]
- sucrose catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SWI/SNF complex [IDA, IMP]
- nucleus [IDA]
SPT15
Gene Ontology Biological Process
Gene Ontology Molecular Function- DNA binding, bending [IDA]
- RNA polymerase I transcription factor binding [IDA, IPI]
- RNA polymerase I transcription factor recruiting transcription factor activity [IDA, IPI]
- RNA polymerase II activating transcription factor binding [IDA, IPI]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [IC]
- RNA polymerase III regulatory region DNA binding [IDA]
- TFIIIB-type transcription factor activity [IC]
- chromatin binding [IDA]
- sequence-specific DNA binding [IDA]
- DNA binding, bending [IDA]
- RNA polymerase I transcription factor binding [IDA, IPI]
- RNA polymerase I transcription factor recruiting transcription factor activity [IDA, IPI]
- RNA polymerase II activating transcription factor binding [IDA, IPI]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [IC]
- RNA polymerase III regulatory region DNA binding [IDA]
- TFIIIB-type transcription factor activity [IC]
- chromatin binding [IDA]
- sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Role for Nhp6, Gcn5, and the Swi/Snf complex in stimulating formation of the TATA-binding protein-TFIIA-DNA complex.
The TATA-binding protein (TBP), TFIIA, and TFIIB interact with promoter DNA to form a complex required for transcriptional initiation, and many transcriptional regulators function by either stimulating or inhibiting formation of this complex. We have recently identified TBP mutants that are viable in wild-type cells but lethal in the absence of the Nhp6 architectural transcription factor. Here we show that ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SNF2 SPT15 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 435672 |
Curated By
- BioGRID