MMS21
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MLP1
Gene Ontology Biological Process
- negative regulation of protein import into nucleus during spindle assembly checkpoint [IGI]
- nuclear retention of unspliced pre-mRNA at the site of transcription [IGI, IMP]
- poly(A)+ mRNA export from nucleus [IMP]
- protein import into nucleus [IGI]
- protein localization to nuclear pore [IMP]
- telomere tethering at nuclear periphery [IGI]
- transcriptional activation by promoter-terminator looping [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization.
Through a genetic screen using myosin-like protein strains mlp1Delta mlp2Delta and biochemical purification, we identified a complex of eight proteins, each required for growth and DNA repair in Saccharomyces cerevisiae. Among the subunits are Mms21 that contains a putative Siz/PIAS (protein inhibitor of activated signal transducer and activator of transcription) RING domain characteristic of small ubiquitin-like modifier (SUMO) ligases, two ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- mms21 mlp1 mlp2 triple mutant
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MMS21 MLP1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.5629 | BioGRID | 1974409 |
Curated By
- BioGRID