RGD1
Gene Ontology Biological Process
Gene Ontology Molecular Function- Rho GTPase activator activity [IDA, IGI]
- phosphatidylinositol-3,5-bisphosphate binding [IDA, IMP]
- phosphatidylinositol-3-phosphate binding [IDA, IMP]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA, IMP]
- phosphatidylinositol-5-phosphate binding [IDA, IMP]
- Rho GTPase activator activity [IDA, IGI]
- phosphatidylinositol-3,5-bisphosphate binding [IDA, IMP]
- phosphatidylinositol-3-phosphate binding [IDA, IMP]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA, IMP]
- phosphatidylinositol-5-phosphate binding [IDA, IMP]
Gene Ontology Cellular Component
MID2
Gene Ontology Biological Process
- UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response [IMP]
- cell morphogenesis involved in conjugation [IGI, IMP]
- fungal-type cell wall organization [IGI, IMP]
- peroxisome degradation [IMP]
- response to acidic pH [IMP]
- response to osmotic stress [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The Rgd1p Rho GTPase-activating protein and the Mid2p cell wall sensor are required at low pH for protein kinase C pathway activation and cell survival in Saccharomyces cerevisiae.
The protein kinase C (PKC) pathway is involved in the maintenance of cell shape and cell integrity in Saccharomyces cerevisiae. Here, we show that this pathway mediates tolerance to low pH and that the Bck1 and Slt2 proteins belonging to the mitogen-activated protein kinase cascade are essential for cell survival at low pH. The PKC pathway is activated during acidification ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- at low PH
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RGD1 MID2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1322 | BioGRID | 360053 | |
| MID2 RGD1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1322 | BioGRID | 400597 | |
| MID2 RGD1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1243 | BioGRID | 2154333 | |
| RGD1 MID2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 156713 | |
| RGD1 MID2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 429586 |
Curated By
- BioGRID