BAIT
RTC3
HGI1, YHR087W
Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress
GO Process (1)
GO Function (0)
GO Component (2)
Saccharomyces cerevisiae (S288c)
PREY
NSR1
SHE5, L000001278, YGR159C
Nucleolar protein that binds nuclear localization sequences; required for pre-rRNA processing and ribosome biogenesis
GO Process (2)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism.
A combination of structural, biochemical, and genetic studies in model organisms was used to infer a cellular role for the human protein (SBDS) responsible for Shwachman-Bodian-Diamond syndrome. The crystal structure of the SBDS homologue in Archaeoglobus fulgidus, AF0491, revealed a three domain protein. The N-terminal domain, which harbors the majority of disease-linked mutations, has a novel three-dimensional fold. The central ... [more]
J. Biol. Chem. May. 13, 2005; 280(19);19213-20 [Pubmed: 15701634]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID