BAIT
SWD3
CPS30, SAF35, YBR175W
Essential subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
GO Process (3)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
SPT4
transcription elongation factor SPT4, L000002030, YGR063C
Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions
GO Process (12)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- 7-methylguanosine mRNA capping [IGI]
- chromatin organization [IMP]
- chromatin silencing [IMP]
- chromosome segregation [IMP]
- intracellular mRNA localization [IMP]
- mRNA splicing, via spliceosome [IMP]
- negative regulation of transcription elongation from RNA polymerase I promoter [IGI]
- positive regulation of transcription elongation from RNA polymerase I promoter [IMP]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- regulation of rRNA processing [IMP]
- regulation of transcription, DNA-templated [IMP]
- regulation of transcription-coupled nucleotide-excision repair [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex.
Histone-lysine methylation is linked to transcriptional regulation and the control of epigenetic inheritance. Lysine residues can be mono-, di-, or trimethylated, and it has been suggested that each methylation state of a given lysine may impart a unique biological function. In yeast, histone H3 lysine 4 (K4) is mono-, di-, and trimethylated by the Set1 histone methyltransferase. Previous studies show ... [more]
Curr. Biol. Aug. 23, 2005; 15(16);1487-93 [Pubmed: 16040246]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID