BAIT
COG5
CDG2I, GOLTC1, GTC90
component of oligomeric golgi complex 5
GO Process (1)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MEFV
FMF, MEF, TRIM20
Mediterranean fever
GO Process (8)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- inflammatory response [IDA]
- innate immune response [TAS]
- negative regulation of inflammatory response [IMP]
- negative regulation of interleukin-1 beta production [IMP]
- negative regulation of interleukin-12 production [IMP]
- negative regulation of macrophage inflammatory protein 1 alpha production [IMP]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- positive regulation of cysteine-type endopeptidase activity [IDA]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The familial mediterranean fever protein interacts and colocalizes with a putative Golgi transporter.
The biological function of pyrin, the protein mutated in Familial Mediterranean Fever (FMF), has not been elucidated. Based on sequence homology, a transcription factor activity was proposed for this neutrophil-specific protein. In a yeast two-hybrid assay, neither transcription activation activity nor any self interaction was detected for pyrin. Screening of an expression cDNA library of peripheral blood leukocytes using as ... [more]
Proc. Soc. Exp. Biol. Med. May. 01, 2000; 224(1);32-40 [Pubmed: 10782044]
Throughput
- Low Throughput
Curated By
- BioGRID