BAIT
XPA
XP1, XPAC, RP11-244N9.4
xeroderma pigmentosum, complementation group A
GO Process (3)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RPA4
HSU24186, RP1-117P19.1
replication protein A4, 30kDa
GO Process (6)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair.
Replication protein A (RPA) is required for simian virus 40-directed DNA replication in vitro and for nucleotide excision repair (NER). Here we report that RPA and the human repair protein XPA specifically interact both in vitro and in vivo. Mapping of the RPA-interactive domains in XPA revealed that both of the largest subunits of RPA, RPA-70 and RPA-34, interact with ... [more]
Mol. Cell. Biol. Oct. 01, 1995; 15(10);5396-402 [Pubmed: 7565690]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID