BAIT
CITED1
MSG1
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
GO Process (33)
GO Function (9)
GO Component (3)
Gene Ontology Biological Process
- SMAD protein signal transduction [IDA]
- branching involved in ureteric bud morphogenesis [ISS]
- cell proliferation [TAS]
- melanin biosynthetic process [ISS]
- melanocyte differentiation [IMP]
- mesenchymal to epithelial transition [TAS]
- metanephros development [TAS]
- negative regulation of Wnt signaling pathway [TAS]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of osteoblast differentiation [ISS]
- negative regulation of transcription, DNA-templated [IDA, ISS]
- nucleocytoplasmic transport [IDA]
- pigmentation [IMP]
- placenta development [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of transforming growth factor beta receptor signaling pathway [TAS]
- regulation of transcription from RNA polymerase II promoter [TAS]
- response to cAMP [ISS]
- response to cytokine [ISS]
- response to estrogen [IDA, TAS]
- response to insulin [ISS]
- response to interferon-gamma [ISS]
- response to interleukin-1 [ISS]
- response to interleukin-11 [ISS]
- response to interleukin-2 [ISS]
- response to interleukin-4 [ISS]
- response to interleukin-6 [ISS]
- response to interleukin-9 [ISS]
- response to lipopolysaccharide [ISS]
- response to parathyroid hormone [ISS]
- response to transforming growth factor beta [IDA]
- transforming growth factor beta receptor signaling pathway [IDA]
Gene Ontology Molecular Function- LBD domain binding [IDA]
- chromatin binding [ISS]
- co-SMAD binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription coactivator activity [IDA]
- transcription regulatory region DNA binding [IDA]
- LBD domain binding [IDA]
- chromatin binding [ISS]
- co-SMAD binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription coactivator activity [IDA]
- transcription regulatory region DNA binding [IDA]
Homo sapiens
PREY
SMAD4
DPC4, JIP, MADH4, MYHRS
SMAD family member 4
GO Process (24)
GO Function (14)
GO Component (9)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, TAS]
- SMAD protein complex assembly [IDA]
- SMAD protein signal transduction [IDA]
- gene expression [TAS]
- intracellular signal transduction [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of protein catabolic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription, DNA-templated [IDA]
- palate development [ISS]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of SMAD protein import into nucleus [ISS]
- positive regulation of epithelial to mesenchymal transition [ISS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, TAS]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- regulation of transforming growth factor beta receptor signaling pathway [IMP]
- regulation of transforming growth factor beta2 production [IMP]
- response to hypoxia [IMP]
- response to transforming growth factor beta [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [IDA, TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- protein binding transcription factor activity [IDA]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- transforming growth factor beta receptor, common-partner cytoplasmic mediator activity [IDA]
- DNA binding [IDA]
- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- protein binding transcription factor activity [IDA]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- transforming growth factor beta receptor, common-partner cytoplasmic mediator activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator.
Smad4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Hetero-oligomerization of Smad4 with the pathway-restricted SMAD proteins is essential for Smad4-mediated transcription. We provide evidence that SMAD hetero-oligomerization is directly required for the Smad4 C-terminal domain [Smad4(C)] to show its transcriptional transactivating activity; this requirement obtains ... [more]
Proc. Natl. Acad. Sci. U.S.A. Aug. 18, 1998; 95(17);9785-90 [Pubmed: 9707553]
Throughput
- Low Throughput
Curated By
- BioGRID