BAIT

ERBB4

ALS19, HER4, p180erbB4
erb-b2 receptor tyrosine kinase 4
GO Process (34)
GO Function (6)
GO Component (9)

Gene Ontology Biological Process

Homo sapiens
PREY

DLG3

MRX, MRX90, NEDLG, PPP1R82, SAP102, XLMR, RP11-291O7.3
discs, large homolog 3 (Drosophila)
GO Process (4)
GO Function (2)
GO Component (2)
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.

Garcia RA, Vasudevan K, Buonanno A

Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of their cognate tyrosine kinase receptors, ErbB 1-4. The subcellular distribution and mechanisms that regulate the localization of ErbB receptors are unknown. We have found that ErbB receptors are present in brain subcellular fractions enriched for postsynaptic densities (PSD). The ErbB-4 receptor is ... [more]

Proc. Natl. Acad. Sci. U.S.A. Mar. 28, 2000; 97(7);3596-601 [Pubmed: 10725395]

Throughput

  • Low Throughput

Curated By

  • BioGRID