BAIT
BCAR1
CAS, CAS1, CASS1, CRKAS, P130Cas, hCG_1980470
breast cancer anti-estrogen resistance 1
GO Process (23)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IDA]
- G-protein coupled receptor signaling pathway [ISS, NAS]
- T cell receptor signaling pathway [NAS]
- actin filament organization [IDA]
- antigen receptor-mediated signaling pathway [IDA]
- blood coagulation [TAS]
- cell chemotaxis [IMP]
- cell division [NAS]
- cell migration [IDA]
- cell proliferation [TAS]
- cellular response to hepatocyte growth factor stimulus [IMP]
- epidermal growth factor receptor signaling pathway [ISS]
- hepatocyte growth factor receptor signaling pathway [IMP]
- insulin receptor signaling pathway [ISS]
- integrin-mediated signaling pathway [IDA]
- neurotrophin TRK receptor signaling pathway [ISS]
- platelet activation [TAS]
- platelet-derived growth factor receptor signaling pathway [ISS]
- positive regulation of cell migration [IDA]
- positive regulation of endothelial cell migration [IDA]
- regulation of apoptotic process [TAS]
- regulation of cell growth [TAS]
- vascular endothelial growth factor receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
PTEN
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
phosphatase and tensin homolog
GO Process (64)
GO Function (11)
GO Component (10)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell receptor signaling pathway [TAS]
- activation of mitotic anaphase-promoting complex activity [IDA]
- apoptotic process [ISS]
- brain morphogenesis [ISS]
- canonical Wnt signaling pathway [IDA]
- cell migration [ISS]
- cell proliferation [TAS]
- central nervous system development [ISS]
- central nervous system myelin maintenance [ISS]
- central nervous system neuron axonogenesis [ISS]
- dendritic spine morphogenesis [ISS]
- dentate gyrus development [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- forebrain morphogenesis [ISS]
- heart development [ISS]
- innate immune response [TAS]
- inositol phosphate dephosphorylation [IDA]
- inositol phosphate metabolic process [TAS]
- learning or memory [ISS]
- locomotor rhythm [ISS]
- locomotory behavior [ISS]
- multicellular organismal response to stress [ISS]
- negative regulation of G1/S transition of mitotic cell cycle [IDA]
- negative regulation of axonogenesis [ISS]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of cell size [ISS]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- negative regulation of dendritic spine morphogenesis [ISS]
- negative regulation of excitatory postsynaptic membrane potential [ISS]
- negative regulation of focal adhesion assembly [IMP]
- negative regulation of organ growth [ISS]
- negative regulation of phosphatidylinositol 3-kinase signaling [TAS]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of synaptic vesicle clustering [ISS]
- neuron-neuron synaptic transmission [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine dephosphorylation [IDA]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol dephosphorylation [IDA, IMP]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipid metabolic process [TAS]
- positive regulation of cell proliferation [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- postsynaptic density assembly [ISS]
- prepulse inhibition [ISS]
- presynaptic membrane assembly [ISS]
- protein dephosphorylation [IDA, TAS]
- protein kinase B signaling [ISS]
- protein stabilization [IDA]
- regulation of cellular component size [ISS]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of neuron projection development [ISS]
- regulation of protein stability [IMP]
- rhythmic synaptic transmission [ISS]
- small molecule metabolic process [TAS]
- social behavior [ISS]
- synapse assembly [ISS]
- synapse maturation [ISS]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- anaphase-promoting complex binding [IPI]
- enzyme binding [IPI]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3-phosphatase activity [IDA]
- phosphoprotein phosphatase activity [IDA]
- protein binding [IPI]
- protein serine/threonine phosphatase activity [IDA]
- protein tyrosine phosphatase activity [IDA]
- PDZ domain binding [IPI]
- anaphase-promoting complex binding [IPI]
- enzyme binding [IPI]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3-phosphatase activity [IDA]
- phosphoprotein phosphatase activity [IDA]
- protein binding [IPI]
- protein serine/threonine phosphatase activity [IDA]
- protein tyrosine phosphatase activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.
PTEN/MMAC1 is a major new tumor suppressor gene that encodes a dual-specificity phosphatase with sequence similarity to the cytoskeletal protein tensin. Recently, we reported that PTEN dephosphorylates focal adhesion kinase (FAK) and inhibits cell migration, spreading, and focal adhesion formation. Here, the effects of PTEN on cell invasion, migration, and growth as well as the involvement of FAK and p130 ... [more]
Cancer Res. Jan. 15, 1999; 59(2);442-9 [Pubmed: 9927060]
Throughput
- Low Throughput
Curated By
- BioGRID