ERV41
Gene Ontology Biological Process
Gene Ontology Cellular Component
PEP4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The Erv41-Erv46 complex serves as a retrograde receptor to retrieve escaped ER proteins.
Signal-dependent sorting of proteins in the early secretory pathway is required for dynamic retention of endoplasmic reticulum (ER) and Golgi components. In this study, we identify the Erv41-Erv46 complex as a new retrograde receptor for retrieval of non-HDEL-bearing ER resident proteins. In cells lacking Erv41-Erv46 function, the ER enzyme glucosidase I (Gls1) was mislocalized and degraded in the vacuole. Biochemical ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: protein/peptide accumulation (APO:0000149)
Additional Notes
- monophenotypic suppressing
- when pep4 deletion was combined with erv41 deletion, the cellular levels of Gls1 were restored to near WT levels
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PEP4 ERV41 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1818 | BioGRID | 2191975 |
Curated By
- BioGRID