BAIT
TLE1
ESG, ESG1, GRG1, RP11-203D19.1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
GO Process (9)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- multicellular organismal development [TAS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of Wnt signaling pathway [NAS]
- negative regulation of anoikis [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- organ morphogenesis [TAS]
- positive regulation of gene expression [IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
FOXA2
HNF3B, TCF3B
forkhead box A2
GO Process (20)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- cell fate specification [ISS]
- dopaminergic neuron differentiation [ISS]
- endocrine pancreas development [IDA]
- negative regulation of detection of glucose [ISS]
- negative regulation of epithelial to mesenchymal transition [IMP]
- negative regulation of glucokinase activity [ISS]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of transcription from RNA polymerase II promoter by glucose [ISS]
- positive regulation of cell-cell adhesion mediated by cadherin [IC]
- positive regulation of embryonic development [ISS]
- positive regulation of gastrulation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter by glucose [ISS]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- primitive streak formation [ISS]
- regulation of blood coagulation [IDA]
- regulation of insulin secretion involved in cellular response to glucose stimulus [ISS]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to interleukin-6 [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.
Members of the hepatic nuclear factor 3 (HNF3) family, including HNF3alpha, HNF3beta, and HNF3gamma, play important roles in embryonic development, the establishment of tissue-specific gene expression, and the regulation of gene expression in differentiated tissues. We found, using the glutathione S-transferase pull-down method, that the transducin-like Enhancer of split (TLE) proteins, which are the human homologs of Drosophila Groucho, directly ... [more]
J. Biol. Chem. Jun. 16, 2000; 275(24);18418-23 [Pubmed: 10748198]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FOXA2 TLE1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID