BAIT
CENPF
CENF, PRO1779, hcp-1, RP11-262H5.1
centromere protein F, 350/400kDa
GO Process (13)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- cell proliferation [NAS]
- chromosome segregation [IMP, NAS]
- kinetochore assembly [NAS]
- metaphase plate congression [IDA]
- mitotic cell cycle [IMP, TAS]
- mitotic spindle assembly checkpoint [NAS]
- negative regulation of transcription, DNA-templated [IDA]
- protein transport [IDA, IMP]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cell cycle [TAS]
- regulation of striated muscle tissue development [ISS]
- response to drug [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CENPF
CENF, PRO1779, hcp-1, RP11-262H5.1
centromere protein F, 350/400kDa
GO Process (13)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- cell proliferation [NAS]
- chromosome segregation [IMP, NAS]
- kinetochore assembly [NAS]
- metaphase plate congression [IDA]
- mitotic cell cycle [IMP, TAS]
- mitotic spindle assembly checkpoint [NAS]
- negative regulation of transcription, DNA-templated [IDA]
- protein transport [IDA, IMP]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cell cycle [TAS]
- regulation of striated muscle tissue development [ISS]
- response to drug [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The C terminus of mitosin is essential for its nuclear localization, centromere/kinetochore targeting, and dimerization.
Mitosin is a novel 350-kDa nuclear phosphoprotein that dramatically relocates from the evenly nuclear distribution in S phase to the centromere/kinetochore and mitotic apparatus in M phase. The dynamic relocalization of mitosin is accompanied by the phosphorylation of itself, suggesting that mitosin plays a role in mitotic progression. The molecular basis of nuclear localization and targeting of mitosin to the ... [more]
J. Biol. Chem. Aug. 18, 1995; 270(33);19545-50 [Pubmed: 7642639]
Throughput
- Low Throughput
Curated By
- BioGRID