TRM8
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PAP2
Gene Ontology Biological Process
- U4 snRNA 3'-end processing [IGI, IMP]
- base-excision repair [IGI, IMP]
- histone mRNA catabolic process [IGI]
- meiotic DNA double-strand break formation [IMP]
- ncRNA polyadenylation [IDA, IGI, IMP]
- negative regulation of DNA recombination [IMP]
- nuclear mRNA surveillance of mRNA 3'-end processing [IGI]
- nuclear polyadenylation-dependent CUT catabolic process [IGI, IMP]
- nuclear polyadenylation-dependent antisense transcript catabolic process [IMP]
- nuclear polyadenylation-dependent mRNA catabolic process [IGI]
- nuclear polyadenylation-dependent rRNA catabolic process [IGI, IMP]
- nuclear polyadenylation-dependent snRNA catabolic process [IMP]
- nuclear polyadenylation-dependent snoRNA catabolic process [IGI, IMP]
- nuclear polyadenylation-dependent tRNA catabolic process [IDA, IGI, IMP]
- polyadenylation-dependent mRNA catabolic process [IMP]
- polyadenylation-dependent snoRNA 3'-end processing [IGI]
- snoRNA polyadenylation [IGI]
- tRNA modification [IMP]
Gene Ontology Molecular Function
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Rapid tRNA decay can result from lack of nonessential modifications.
The biological role of many nonessential tRNA modifications outside of the anticodon remains elusive despite their evolutionary conservation. We show here that m7G46 methyltransferase Trm8p/Trm82p acts as a hub of synthetic interactions with several tRNA modification enzymes, resulting in temperature-sensitive growth. Analysis of three double mutants indicates reduced levels of tRNA(Val(AAC)), consistent with a role of the corresponding modifications in ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: heat sensitivity (APO:0000147)
Additional Notes
- Deletion of trf4 partially rescues a trm8 trm4 double mutant at 33 C but not 37 C.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
TRM8 PAP2 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 520724 | |
TRM8 PAP2 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 298532 |
Curated By
- BioGRID