NCB2
Gene Ontology Biological Process
- RNA polymerase II transcriptional preinitiation complex assembly [IMP]
- negative regulation of tRNA transcription from RNA polymerase III promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter in response to heat stress [IMP]
- regulation of RNA polymerase II transcriptional preinitiation complex assembly [IMP]
Gene Ontology Molecular Function- TBP-class protein binding RNA polymerase II transcription factor activity [IDA, IPI]
- TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [IMP]
- chromatin binding [IDA]
- core promoter binding [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IGI, IMP]
- TBP-class protein binding RNA polymerase II transcription factor activity [IDA, IPI]
- TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [IMP]
- chromatin binding [IDA]
- core promoter binding [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IGI, IMP]
Gene Ontology Cellular Component
SET2
Gene Ontology Biological Process
- DNA-templated transcription, elongation [IDA, IPI]
- DNA-templated transcription, termination [IMP]
- ascospore formation [IMP]
- histone deacetylation [IMP]
- histone methylation [IDA, IMP]
- negative regulation of antisense RNA transcription [IMP]
- negative regulation of histone H3-K14 acetylation [IMP]
- negative regulation of histone H3-K9 acetylation [IMP]
- negative regulation of reciprocal meiotic recombination [IMP]
- positive regulation of histone acetylation [IGI]
- regulation of DNA-dependent DNA replication initiation [IMP]
- regulation of histone exchange [IMP]
- regulation of transcription, DNA-templated [IDA, IMP]
Gene Ontology Molecular Function
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global genetic interaction network maps a wiring diagram of cellular function.
We generated a global genetic interaction network for Saccharomyces cerevisiae, constructing more than 23 million double mutants, identifying about 550,000 negative and about 350,000 positive genetic interactions. This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential genes as densely connected hubs. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to ... [more]
Quantitative Score
- -0.1274 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions.
- alleles: ncb2-5009 - set2 [SGA score = -0.1274, P-value = 0.002921]
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
NCB2 SET2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 1240303 | |
SET2 NCB2 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 1240306 | |
NCB2 SET2 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 1240282 |
Curated By
- BioGRID