SWI5
Gene Ontology Biological Process
Gene Ontology Molecular Function
RPD3
Gene Ontology Biological Process
- chromatin organization involved in regulation of transcription [IMP]
- histone H3 deacetylation [IMP]
- histone H4 deacetylation [IMP]
- negative regulation of chromatin silencing at rDNA [IMP]
- negative regulation of chromatin silencing at silent mating-type cassette [IMP]
- negative regulation of chromatin silencing at telomere [IDA, IMP]
- negative regulation of reciprocal meiotic recombination [IMP]
- negative regulation of transcription during meiosis [IMP]
- negative regulation of transcription from RNA polymerase I promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP, IPI]
- positive regulation of macroautophagy [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- protein localization to nucleolar rDNA repeats [IMP]
- regulation of DNA-dependent DNA replication initiation [IGI, IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI, IPI]
- regulation of transcription involved in G2/M transition of mitotic cell cycle [IGI]
- replicative cell aging [IMP]
- transcription elongation from RNA polymerase II promoter [IGI]
- transfer RNA gene-mediated silencing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Both positive and negative regulators of HO transcription are required for mother-cell-specific mating-type switching in yeast.
The HO gene, which encodes an endonuclease responsible for initiating mating type switching in yeast, is transcribed at START during the cell cycle of mother cells but not at all during the cell cycle of daughter cells. At least six genes, called SWI1-6, are necessary for HO transcription. We describe the isolation and characterization of mutations in two new genes ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: mating type switching (APO:0000196)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RPD3 SWI5 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1252 | BioGRID | 407203 | |
| SWI5 RPD3 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 261692 |
Curated By
- BioGRID