TOP1
Gene Ontology Biological Process
- DNA strand elongation involved in DNA replication [IMP]
- DNA topological change [IDA, IMP]
- chromatin assembly or disassembly [IMP]
- chromatin silencing at rDNA [IMP]
- mitotic chromosome condensation [IGI, IMP]
- nuclear migration [IGI, IMP]
- regulation of mitotic recombination [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP]
- transcription elongation from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
CSL4
Gene Ontology Biological Process
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IMP]
- ncRNA 3'-end processing [IC]
- nonfunctional rRNA decay [IC]
- nuclear polyadenylation-dependent mRNA catabolic process [IC]
- nuclear polyadenylation-dependent rRNA catabolic process [IMP]
- nuclear polyadenylation-dependent tRNA catabolic process [IDA]
- nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [IC]
- nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [IGI, IMP]
- nuclear-transcribed mRNA catabolic process, non-stop decay [IMP]
- polyadenylation-dependent snoRNA 3'-end processing [IC]
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
"Superkiller" mutations suppress chromosomal mutations affecting double-stranded RNA killer plasmid replication in saccharomyces cerevisiae.
Saccharomyces cerevisiae strains carrying a 1.5 x 10(6)-dalton double-stranded RNA genome in virus-like particles (killer plasmid) secrete a protein toxin that kills strains not carrying this plasmid. At least 28 chromosomal genes (mak genes) are required to maintain or replicate this plasmid. Recessive mutations in any of four other chromosomal genes (ski for superkiller) result in enhanced toxin production. We ... [more]
Throughput
- Low Throughput
Ontology Terms
- chromosome/plasmid maintenance (APO:0000143)
Additional Notes
- ski4 suppresses mak1 mutation by retaining killer plasmid
- ski4 suppresses mak17 mutation by retaining killer plasmid
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CSL4 TOP1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.4437 | BioGRID | 2011658 |
Curated By
- BioGRID