BAIT

FLC1

BOP1, HUF1, L000004721, YPL221W
Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC1 has a paralog, FLC3, that arose from the whole genome duplication
GO Process (3)
GO Function (1)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

FLC3

HUF3, YGL139W
Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER; FLC3 has a paralog, FLC1, that arose from the whole genome duplication
GO Process (2)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum.

Protchenko O, Rodriguez-Suarez R, Androphy R, Bussey H, Philpott CC

Although Candida albicans and Saccharomyces cerevisiae express very similar systems of iron uptake, these species differ in their capacity to use heme as a nutritional iron source. Whereas C. albicans efficiently takes up heme, S. cerevisiae grows poorly on media containing heme as the sole source of iron. We identified a gene from C. albicans that would enhance heme uptake ... [more]

J. Biol. Chem. Jul. 28, 2006; 281(30);21445-57 [Pubmed: 16717099]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: nutrient utilization (APO:0000096)

Additional Notes

  • genetic complex
  • suppressor of flc1flc2 lethality on methionine-containing medium

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
FLC1 FLC3
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
2388346

Curated By

  • BioGRID