BAIT

FLC2

FAD transporter FLC2, HUF2, YAL053W
Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
GO Process (4)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

SKG3

YLR187W
Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication
GO Process (0)
GO Function (0)
GO Component (4)

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum.

Protchenko O, Rodriguez-Suarez R, Androphy R, Bussey H, Philpott CC

Although Candida albicans and Saccharomyces cerevisiae express very similar systems of iron uptake, these species differ in their capacity to use heme as a nutritional iron source. Whereas C. albicans efficiently takes up heme, S. cerevisiae grows poorly on media containing heme as the sole source of iron. We identified a gene from C. albicans that would enhance heme uptake ... [more]

J. Biol. Chem. Jul. 28, 2006; 281(30);21445-57 [Pubmed: 16717099]

Throughput

  • Low Throughput

Ontology Terms

  • nutrient utilization (APO:0000096)

Additional Notes

  • genetic complex
  • suppressor of flc1flc2 lethality on methionine-containing medium

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
FLC2 SKG3
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.8447BioGRID
2076335

Curated By

  • BioGRID