SUM1
Gene Ontology Biological Process
- chromatin silencing at silent mating-type cassette [IGI, IMP]
- negative regulation of transcription by competitive promoter binding [IDA]
- negative regulation of transcription from RNA polymerase II promoter during mitosis [IMP]
- positive regulation of DNA-dependent DNA replication initiation [IGI, IMP, IPI]
Gene Ontology Molecular Function- DNA replication origin binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- sequence-specific DNA binding [IDA]
- DNA replication origin binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- sequence-specific DNA binding [IDA]
ACT1
Gene Ontology Biological Process
- DNA repair [IDA]
- actomyosin contractile ring contraction [IDA, IMP]
- ascospore wall assembly [IDA]
- budding cell isotropic bud growth [TAS]
- cellular response to oxidative stress [IGI]
- chronological cell aging [IMP]
- endocytosis [IMP]
- establishment of cell polarity [IGI]
- establishment of mitotic spindle orientation [TAS]
- exocytosis [TAS]
- fungal-type cell wall organization [TAS]
- histone acetylation [IDA]
- mitochondrion inheritance [TAS]
- protein secretion [IGI, IMP]
- vacuole inheritance [IGI, IMP]
- vesicle transport along actin filament [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global genetic interaction network maps a wiring diagram of cellular function.
We generated a global genetic interaction network for Saccharomyces cerevisiae, constructing more than 23 million double mutants, identifying about 550,000 negative and about 350,000 positive genetic interactions. This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential genes as densely connected hubs. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to ... [more]
Quantitative Score
- -0.3259 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions.
- alleles: sum1 - act1-119 [SGA score = -0.1352, P-value = 8.32E-5]
- alleles: sum1 - act1-120 [SGA score = -0.2082, P-value = 0.00352]
- alleles: sum1 - act1-121 [SGA score = -0.1898, P-value = 0.003189]
- alleles: sum1 - act1-122 [SGA score = -0.1622, P-value = 2.501E-26]
- alleles: sum1 - act1-124 [SGA score = -0.2487, P-value = 0.008686]
- alleles: sum1 - act1-129 [SGA score = -0.2285, P-value = 0.0003971]
- alleles: sum1 - act1-132 [SGA score = -0.1679, P-value = 0.00672]
- alleles: sum1 - act1-136 [SGA score = -0.3259, P-value = 2.108E-5]
- alleles: sum1 - act1-155 [SGA score = -0.1725, P-value = 1.85E-14]
- alleles: sum1 - act1-159 [SGA score = -0.1746, P-value = 0.0003319]
- alleles: sum1 - act1-3 [SGA score = -0.2167, P-value = 0.01881]
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ACT1 SUM1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2128 | BioGRID | 376955 | |
| ACT1 SUM1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.4534 | BioGRID | 1979266 | |
| SUM1 ACT1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.5871 | BioGRID | 2435274 | |
| ACT1 SUM1 | Synthetic Haploinsufficiency Synthetic Haploinsufficiency A genetic interaction is inferred when mutations or deletions in separate genes, at least one of which is hemizygous, cause a minimal phenotype alone but result in lethality when combined in the same cell under a given condition. | High | - | BioGRID | 281574 |
Curated By
- BioGRID