BAIT
TTF1
TTF-1, TTF-I
transcription termination factor, RNA polymerase I
GO Process (4)
GO Function (0)
GO Component (5)
Gene Ontology Biological Process
Homo sapiens
PREY
PTRF
CAVIN, CAVIN1, CGL4, cavin-1, FKSG13
polymerase I and transcript release factor
GO Process (4)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes.
Termination of transcription by RNA polymerase I (Pol I) is a two-step process which involves pausing of elongating transcription complexes and release of both pre-rRNA and Pol I from the template. In mouse, pausing of elongation complexes is mediated by the transcription termination factor TTF-I bound to the 'Sal box' terminator downstream of the rDNA transcription unit. Dissociation of paused ... [more]
EMBO J. May. 15, 1998; 17(10);2855-64 [Pubmed: 9582279]
Throughput
- Low Throughput
Curated By
- BioGRID