SAC3
Gene Ontology Biological Process
- actin filament-based process [IGI]
- mRNA 3'-end processing [IMP]
- mRNA export from nucleus [IGI, IMP, IPI]
- mitotic nuclear division [IMP]
- nuclear retention of pre-mRNA at the site of transcription [IMP]
- posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [IMP]
- protein export from nucleus [IGI, IMP]
- ribosomal small subunit biogenesis [IMP]
- transcription-coupled nucleotide-excision repair [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NUP100
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [IGI]
- mRNA export from nucleus [IPI]
- mRNA export from nucleus in response to heat stress [IMP]
- positive regulation of transcription, DNA-templated [IGI]
- posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [IMP]
- protein import into nucleus [IGI]
- protein targeting to nuclear inner membrane [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A global genetic interaction network maps a wiring diagram of cellular function.
We generated a global genetic interaction network for Saccharomyces cerevisiae, constructing more than 23 million double mutants, identifying about 550,000 negative and about 350,000 positive genetic interactions. This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential genes as densely connected hubs. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to ... [more]
Quantitative Score
- -0.1249 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions.
- alleles: sac3 - nup100 [SGA score = -0.1249, P-value = 0.006475]
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SAC3 NUP100 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| NUP100 SAC3 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1361 | BioGRID | 394274 | |
| NUP100 SAC3 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1529 | BioGRID | 2142723 | |
| NUP100 SAC3 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -4.3309 | BioGRID | 308549 |
Curated By
- BioGRID