BAIT
CSPG4
HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
chondroitin sulfate proteoglycan 4
GO Process (9)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- chondroitin sulfate biosynthetic process [TAS]
- chondroitin sulfate catabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- dermatan sulfate biosynthetic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- intracellular signal transduction [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GRIP2
glutamate receptor interacting protein 2
GO Process (1)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling.
The proteoglycan NG2 is expressed by immature glial cells in the developing and adult central nervous system. Using the COOH-terminal region of NG2 as bait in a yeast two-hybrid screen, we identified the glutamate receptor interaction protein GRIP1, a multi-PDZ domain protein, as an interacting partner. NG2 exhibits a PDZ binding motif at the extreme COOH terminus which binds to ... [more]
J. Biol. Chem. Feb. 07, 2003; 278(6);3590-8 [Pubmed: 12458226]
Throughput
- Low Throughput
Curated By
- BioGRID