BAIT
ITGA3
CD49C, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
GO Process (13)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell-matrix adhesion [TAS]
- extracellular matrix organization [TAS]
- leukocyte migration [TAS]
- lung development [IMP]
- mesodermal cell differentiation [IEP]
- nephron development [IMP]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- regulation of BMP signaling pathway [IMP]
- regulation of Wnt signaling pathway [IMP]
- regulation of transforming growth factor beta receptor signaling pathway [IMP]
- renal filtration [IMP]
- skin development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BIN1
AMPH2, AMPHL, SH3P9
bridging integrator 1
GO Process (6)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains.
The alpha3Abeta1 integrin is a laminin receptor with a broad specificity for different laminin isoforms. Furthermore, it regulates the function of other integrins, like alpha2beta1, alpha5beta1 and alpha6Abeta1. In a yeast two hybrid screen of a human placenta cDNA library, we identified cDNAs coding for four different proteins that strongly interact with the conserved region of the cytoplasmic domain of ... [more]
FEBS Lett. Feb. 26, 1999; 445(2);351-5 [Pubmed: 10094488]
Throughput
- Low Throughput
Curated By
- BioGRID