SAC6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CMD1
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [IMP]
- cell budding [IMP]
- cytoskeleton organization [IMP]
- karyogamy involved in conjugation with cellular fusion [IGI, IMP]
- microautophagy [IMP]
- phosphatidylinositol biosynthetic process [IGI, IMP]
- receptor-mediated endocytosis [IMP]
- spindle pole body organization [IMP]
- transcription factor import into nucleus [IMP]
- vacuole fusion, non-autophagic [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fimbrin phosphorylation by metaphase Cdk1 regulates actin cable dynamics in budding yeast.
Actin cables, composed of actin filament bundles nucleated by formins, mediate intracellular transport for cell polarity establishment and maintenance. We previously observed that metaphase cells preferentially promote actin cable assembly through cyclin-dependent kinase 1 (Cdk1) activity. However, the relevant metaphase Cdk1 targets were not known. Here we show that the highly conserved actin filament crosslinking protein fimbrin is a critical ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SAC6 CMD1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.168 | BioGRID | 2034435 |
Curated By
- BioGRID