BAIT
C21ORF59
C21orf48, CILD26, FBB18
chromosome 21 open reading frame 59
GO Process (0)
GO Function (0)
GO Component (2)
Homo sapiens
PREY
CTNNB1
CTNNB, MRD19, armadillo, OK/SW-cl.35
catenin (cadherin-associated protein), beta 1, 88kDa
GO Process (48)
GO Function (20)
GO Component (23)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- adherens junction assembly [IMP]
- androgen receptor signaling pathway [NAS]
- apoptotic process [TAS]
- canonical Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [IMP]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [ISS]
- canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [IMP]
- cell adhesion [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to growth factor stimulus [IMP]
- cellular response to indole-3-methanol [IDA]
- embryonic skeletal limb joint morphogenesis [ISS]
- endothelial tube morphogenesis [IMP]
- epithelial to mesenchymal transition [TAS]
- hair cell differentiation [TAS]
- innate immune response [TAS]
- muscle cell differentiation [TAS]
- negative regulation of cell proliferation [IDA]
- negative regulation of mitotic cell cycle, embryonic [ISS]
- negative regulation of protein sumoylation [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- patterning of blood vessels [IC]
- positive regulation of DNA-templated transcription, initiation [IC]
- positive regulation of apoptotic process [IDA]
- positive regulation of epithelial to mesenchymal transition [IGI]
- positive regulation of heparan sulfate proteoglycan biosynthetic process [IMP]
- positive regulation of histone H3-K4 methylation [IC]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of neuroblast proliferation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of type I interferon production [TAS]
- protein localization to cell surface [IMP]
- regulation of angiogenesis [TAS]
- regulation of calcium ion import [IDA]
- regulation of cell fate specification [IBA]
- regulation of centriole-centriole cohesion [IDA]
- regulation of centromeric sister chromatid cohesion [IMP]
- regulation of fibroblast proliferation [TAS]
- regulation of nephron tubule epithelial cell differentiation [ISS]
- regulation of protein localization to cell surface [IDA]
- regulation of smooth muscle cell proliferation [IMP]
- response to drug [IEP]
- response to estradiol [IDA]
- single organismal cell-cell adhesion [IMP]
- stem cell maintenance [TAS]
- sympathetic ganglion development [ISS]
Gene Ontology Molecular Function- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II activating transcription factor binding [IPI]
- SMAD binding [IPI]
- alpha-catenin binding [IPI]
- androgen receptor binding [NAS]
- cadherin binding [IPI]
- enzyme binding [IPI]
- estrogen receptor binding [IPI]
- euchromatin binding [IDA]
- ion channel binding [IPI]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI, TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- signal transducer activity [NAS]
- transcription coactivator activity [IDA, IMP]
- transcription factor binding [IPI, TAS]
- transcription regulatory region DNA binding [IDA]
- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II activating transcription factor binding [IPI]
- SMAD binding [IPI]
- alpha-catenin binding [IPI]
- androgen receptor binding [NAS]
- cadherin binding [IPI]
- enzyme binding [IPI]
- estrogen receptor binding [IPI]
- euchromatin binding [IDA]
- ion channel binding [IPI]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI, TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- signal transducer activity [NAS]
- transcription coactivator activity [IDA, IMP]
- transcription factor binding [IPI, TAS]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
- adherens junction [IDA]
- beta-catenin destruction complex [IDA]
- beta-catenin-TCF7L2 complex [IDA]
- catenin complex [IDA]
- cell cortex [IDA]
- cell junction [IDA, TAS]
- cell periphery [IDA]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA]
- centrosome [IDA]
- cytoplasm [IDA]
- cytosol [IDA, TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- lateral plasma membrane [IDA]
- membrane [ISS]
- nuclear euchromatin [IDA]
- nucleoplasm [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- protein-DNA complex [IDA]
- transcription factor complex [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Gene essentiality and synthetic lethality in haploid human cells.
Although the genes essential for life have been identified in less complex model organisms, their elucidation in human cells has been hindered by technical barriers. We used extensive mutagenesis in haploid human cells to identify approximately 2000 genes required for optimal fitness under culture conditions. To study the principles of genetic interactions in human cells, we created a synthetic lethality ... [more]
Science Nov. 27, 2015; 350(6264);1092-6 [Pubmed: 26472760]
Throughput
- Low Throughput
Additional Notes
- High-confidence protein interaction
Curated By
- BioGRID