BAIT
DIEXF
C1orf107, DEF, DJ434O14.5, UTP25, RP3-434O14.6
digestive organ expansion factor homolog (zebrafish)
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AP2S1
AP17, CLAPS2, FBH3, FBHOk, HHC3
adaptor-related protein complex 2, sigma 1 subunit
GO Process (11)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- clathrin coat assembly [TAS]
- clathrin-mediated endocytosis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of defense response to virus by virus [TAS]
- regulation of endocytosis [TAS]
- synaptic transmission [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Gene essentiality and synthetic lethality in haploid human cells.
Although the genes essential for life have been identified in less complex model organisms, their elucidation in human cells has been hindered by technical barriers. We used extensive mutagenesis in haploid human cells to identify approximately 2000 genes required for optimal fitness under culture conditions. To study the principles of genetic interactions in human cells, we created a synthetic lethality ... [more]
Science Nov. 27, 2015; 350(6264);1092-6 [Pubmed: 26472760]
Throughput
- Low Throughput
Additional Notes
- High-confidence protein interaction
Curated By
- BioGRID