BAIT
PTAR1
RP11-109D9.2
protein prenyltransferase alpha subunit repeat containing 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
PIKFYVE
CFD, FAB1, HEL37, PIP5K, PIP5K3, ZFYVE29
phosphoinositide kinase, FYVE finger containing
GO Process (8)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol phosphorylation [TAS]
- phosphatidylinositol-3-phosphate biosynthetic process [TAS]
- phospholipid metabolic process [TAS]
- protein localization to nucleus [IMP]
- receptor-mediated endocytosis [IMP]
- retrograde transport, endosome to Golgi [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Gene essentiality and synthetic lethality in haploid human cells.
Although the genes essential for life have been identified in less complex model organisms, their elucidation in human cells has been hindered by technical barriers. We used extensive mutagenesis in haploid human cells to identify approximately 2000 genes required for optimal fitness under culture conditions. To study the principles of genetic interactions in human cells, we created a synthetic lethality ... [more]
Science Nov. 27, 2015; 350(6264);1092-6 [Pubmed: 26472760]
Throughput
- Low Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
Additional Notes
- Aphenotypic negative genetic interaction (Synonym: Synthetic)
- The authors note that their method cannot clearly distinguish between synthetic lethal or synthetic sick interactions (Figure 3B).
Curated By
- BioGRID