BAIT
PTAR1
RP11-109D9.2
protein prenyltransferase alpha subunit repeat containing 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
BRD4
CAP, HUNK1, HUNKI, MCAP
bromodomain containing 4
GO Process (10)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IMP]
- chromatin remodeling [IDA]
- negative regulation of DNA damage checkpoint [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of transcription elongation from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of inflammatory response [IDA]
- regulation of phosphorylation of RNA polymerase II C-terminal domain [IDA]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Gene essentiality and synthetic lethality in haploid human cells.
Although the genes essential for life have been identified in less complex model organisms, their elucidation in human cells has been hindered by technical barriers. We used extensive mutagenesis in haploid human cells to identify approximately 2000 genes required for optimal fitness under culture conditions. To study the principles of genetic interactions in human cells, we created a synthetic lethality ... [more]
Science Nov. 27, 2015; 350(6264);1092-6 [Pubmed: 26472760]
Throughput
- Low Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
Additional Notes
- Aphenotypic negative genetic interaction (Synonym: Synthetic)
- The authors note that their method cannot clearly distinguish between synthetic lethal or synthetic sick interactions (Figure 3B).
Curated By
- BioGRID