FGFR1
Gene Ontology Biological Process
- angiogenesis [ISO]
- auditory receptor cell development [ISO]
- blood vessel morphogenesis [ISO]
- brain development [ISO]
- branching involved in salivary gland morphogenesis [ISO]
- cell maturation [ISO]
- central nervous system neuron development [IMP]
- chondrocyte differentiation [ISO]
- embryonic limb morphogenesis [ISO]
- fibroblast growth factor receptor signaling pathway [ISO, ISS]
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [ISO]
- generation of neurons [ISO]
- in utero embryonic development [ISO]
- inner ear morphogenesis [ISO]
- lung development [ISO]
- lung-associated mesenchyme development [ISO]
- mesenchymal cell differentiation [ISO]
- midbrain development [ISO]
- middle ear morphogenesis [ISO]
- motogenic signaling involved in postnatal olfactory bulb interneuron migration [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- neuron projection development [IDA]
- orbitofrontal cortex development [ISO]
- organ induction [ISO]
- outer ear morphogenesis [ISO]
- paraxial mesoderm development [ISO]
- peptidyl-tyrosine phosphorylation [ISO, ISS]
- positive regulation of MAP kinase activity [ISO, ISS]
- positive regulation of MAPK cascade [ISO]
- positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [ISO]
- positive regulation of cardiac muscle cell proliferation [ISO]
- positive regulation of cell cycle [ISO]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of mesenchymal cell proliferation [IMP, ISO]
- positive regulation of neuron differentiation [ISO, ISS]
- positive regulation of neuron projection development [IDA, ISO]
- positive regulation of phospholipase C activity [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein autophosphorylation [ISO, ISS]
- regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [ISO]
- regulation of cell proliferation [IDA, ISO]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- regulation of gene expression [ISO]
- regulation of lateral mesodermal cell fate specification [ISO]
- regulation of sensory perception of pain [IMP]
- regulation of stem cell proliferation [IMP]
- salivary gland morphogenesis [ISO]
- sensory perception of sound [ISO]
- stem cell maintenance [IMP]
- ureteric bud development [ISO]
- ventricular zone neuroblast division [ISO]
Gene Ontology Molecular Function- cell adhesion molecule binding [IPI]
- fibroblast growth factor binding [ISO, ISS]
- fibroblast growth factor-activated receptor activity [ISO, ISS, TAS]
- glycoprotein binding [IDA]
- heparin binding [ISO, ISS]
- identical protein binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein homodimerization activity [ISO]
- protein tyrosine kinase activity [ISO]
- cell adhesion molecule binding [IPI]
- fibroblast growth factor binding [ISO, ISS]
- fibroblast growth factor-activated receptor activity [ISO, ISS, TAS]
- glycoprotein binding [IDA]
- heparin binding [ISO, ISS]
- identical protein binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein homodimerization activity [ISO]
- protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
RPS6KA1
Gene Ontology Biological Process
- negative regulation of apoptotic process [ISO, ISS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of hepatic stellate cell activation [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling.
Fibroblast growth factor receptor 1 (FGFR1) is a transmembrane protein capable of transducing stimulation by secreted FGFs. In addition, newly synthesized FGFR1 enters the nucleus in response to cellular stimulation and during development. Nuclear FGFR1 can transactivate CRE (cAMP responsive element), activate CRE-binding protein (CREB)-binding protein (CBP) and gene activities causing cellular growth and differentiation. Here, a yeast two-hybrid assay ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RPS6KA1 FGFR1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID