BAIT

DMC1

ISC2, recombinase DMC1, L000000509, YER179W
Meiosis-specific recombinase required for repair of double-strand breaks; also required for pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p
GO Process (3)
GO Function (3)
GO Component (2)
Saccharomyces cerevisiae (S288c)
PREY

RED1

L000001608, YLR263W
Protein component of the synaptonemal complex axial elements; involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; promotes interhomolog recombination by phosphorylating Hop1p; also interacts with Mec3p and Ddc1p;
GO Process (3)
GO Function (2)
GO Component (1)
Saccharomyces cerevisiae (S288c)

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Prevention of DNA Rereplication Through a Meiotic Recombination Checkpoint Response.

Najor NA, Weatherford L, Brush GS

In the budding yeast Saccharomyces cerevisiae, unnatural stabilization of the cyclin-dependent kinase inhibitor Sic1 during meiosis can trigger extra rounds of DNA replication. When programmed DNA double-strand breaks are generated but not repaired due to absence of DMC1, a pathway involving the checkpoint gene RAD17 prevents this DNA rereplication. Further genetic analysis has now revealed that prevention of DNA rereplication ... [more]

G3 (Bethesda) Sep. 27, 2016; 0(0); [Pubmed: 27678521]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: chromosome/plasmid maintenance (APO:0000143)

Additional Notes

  • deletion allows DNA re-replication in a sic1 background which is inhibited by the absence of dmc1

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
DMC1 RED1
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
506416
DMC1 RED1
Synthetic Rescue
Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Low-BioGRID
159874

Curated By

  • BioGRID