GRIA2
Gene Ontology Biological Process
- establishment of protein localization [IMP]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IBA, ISO, ISS]
- positive regulation of synaptic transmission [IMP]
- protein tetramerization [IDA]
- receptor internalization [IDA]
- regulation of receptor recycling [IMP]
- regulation of synaptic transmission, glutamatergic [IMP]
- response to fungicide [IEP]
- response to lithium ion [IEP]
- synaptic transmission [IDA, ISO]
Gene Ontology Molecular Function- PDZ domain binding [IDA, IPI]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, TAS]
- calcium channel regulator activity [TAS]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA, ISO, TAS]
- kainate selective glutamate receptor activity [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- receptor activity [IDA]
- PDZ domain binding [IDA, IPI]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, TAS]
- calcium channel regulator activity [TAS]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA, ISO, TAS]
- kainate selective glutamate receptor activity [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- receptor activity [IDA]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [IDA]
- cell surface [IDA]
- dendrite [IDA]
- dendrite cytoplasm [IDA]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- endoplasmic reticulum [ISO]
- growth cone [IDA]
- integral component of plasma membrane [IDA]
- ionotropic glutamate receptor complex [TAS]
- membrane [ISO]
- neuron projection [ISO]
- neuronal cell body [IDA]
- perikaryon [IDA]
- postsynaptic density [IDA]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IDA]
- protein complex [IDA, IPI]
- synapse [IDA, ISO]
- synaptic vesicle [ISO]
- synaptic vesicle membrane [IDA]
- terminal bouton [IDA]
NSF
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO, TAS]
- Golgi to plasma membrane protein transport [IBA]
- Golgi vesicle docking [IBA]
- intra-Golgi vesicle-mediated transport [IBA]
- membrane fusion [TAS]
- neurotransmitter secretion [TAS]
- positive regulation of receptor recycling [ISO]
- potassium ion transport [ISO]
- protein transport [IMP]
- regulation of exocytosis [IMP]
- vesicle fusion [TAS]
- vesicle-mediated transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Protein-protein coupling/uncoupling enables dopamine D2 receptor regulation of AMPA receptor-mediated excitotoxicity.
here is considerable evidence that dopamine D2 receptors can modulate AMPA receptor-mediated neurotoxicity. However, the molecular mechanism underlying this process remains essentially unclear. Here we report that D2 receptors inhibit AMPA-mediated neurotoxicity through two pathways: the activation of phosphoinositide-3 kinase (PI-3K) and downregulation of AMPA receptor plasma membrane expression, both involving a series of protein-protein coupling/uncoupling events. Agonist stimulation of ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
GRIA2 NSF | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID