BAIT
DAO
Dao1
D-amino-acid oxidase
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SLC12A5
Kcc2
solute carrier family 12 (potassium-chloride transporter), member 5
GO Process (12)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- ammonium transmembrane transport [IDA]
- ammonium transport [IDA]
- cation transmembrane transport [ISO]
- chloride transmembrane transport [IDA, ISO]
- chloride transport [IDA, ISO]
- intracellular pH reduction [IDA]
- learning [ISO]
- multicellular organism growth [ISO]
- potassium ion transport [IDA]
- response to drug [ISO]
- synaptic transmission [ISO]
- thermosensory behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Schizophrenia is a highly heritable neuropsychiatric disorder affecting ∼1% of the world's population. Linkage and association studies have identified multiple candidate schizophrenia susceptibility genes whose functions converge on the glutamatergic neurotransmitter system. One such susceptibility gene encoding D-amino acid oxidase (DAO), an enzyme that metabolizes the NMDA receptor (NMDAR) co-agonist D-serine, has the potential to modulate NMDAR function in the ... [more]
J. Biol. Chem. Aug. 19, 2011; 286(33);28867-75 [Pubmed: 21700703]
Throughput
- Low Throughput
Curated By
- BioGRID