BAIT
DAO
Dao1
D-amino-acid oxidase
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
AQP4
AQP-4, MIWC2, Miwc
aquaporin 4
GO Process (24)
GO Function (3)
GO Component (12)
Gene Ontology Biological Process
- carbon dioxide transport [IDA]
- cellular response to estradiol stimulus [IEP]
- cellular response to glucose stimulus [IMP]
- cellular response to interferon-gamma [ISO]
- cellular response to interleukin-1 [IEP]
- cellular response to interleukin-6 [IEP]
- cellular water homeostasis [IBA]
- female pregnancy [IEP]
- glycerol transport [IBA]
- hyperosmotic salinity response [IEP]
- ion transmembrane transport [IBA]
- multicellular organismal water homeostasis [ISO]
- negative regulation of cell adhesion molecule production [IMP]
- negative regulation of interleukin-1 beta production [IMP]
- negative regulation of interleukin-6 production [IMP]
- protein homooligomerization [IDA]
- regulation of vascular endothelial growth factor production [IMP]
- renal water absorption [ISO]
- response to glucocorticoid [IEP]
- response to radiation [IEP]
- sensory perception of sound [ISO]
- transmembrane transport [ISO]
- water homeostasis [ISO]
- water transport [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [IDA]
- basal plasma membrane [IDA]
- basolateral plasma membrane [IDA, ISO]
- cell projection membrane [IDA]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- external side of plasma membrane [ISO]
- integral component of plasma membrane [IDA]
- membrane [IDA]
- plasma membrane [ISO]
- protein complex [IDA]
- sarcolemma [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Schizophrenia is a highly heritable neuropsychiatric disorder affecting ∼1% of the world's population. Linkage and association studies have identified multiple candidate schizophrenia susceptibility genes whose functions converge on the glutamatergic neurotransmitter system. One such susceptibility gene encoding D-amino acid oxidase (DAO), an enzyme that metabolizes the NMDA receptor (NMDAR) co-agonist D-serine, has the potential to modulate NMDAR function in the ... [more]
J. Biol. Chem. Aug. 19, 2011; 286(33);28867-75 [Pubmed: 21700703]
Throughput
- Low Throughput
Curated By
- BioGRID