BAIT
DAO
Dao1
D-amino-acid oxidase
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SLC1A2
Eaat2, Glt, Glt-1
solute carrier family 1 (glial high affinity glutamate transporter), member 2
GO Process (18)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- D-aspartate import [ISO]
- L-glutamate import [ISO]
- L-glutamate transmembrane transport [IMP, ISO, TAS]
- L-glutamate transport [IMP, ISO]
- adult behavior [ISO]
- cellular response to extracellular stimulus [ISO]
- multicellular organism growth [ISO]
- multicellular organismal aging [ISO]
- nervous system development [ISO]
- neurotransmitter transport [TAS]
- positive regulation of glucose import [ISO]
- response to amino acid [ISO]
- response to drug [ISO]
- response to light stimulus [ISO]
- response to wounding [ISO]
- sodium ion transmembrane transport [ISO]
- telencephalon development [ISO]
- visual behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Schizophrenia is a highly heritable neuropsychiatric disorder affecting ∼1% of the world's population. Linkage and association studies have identified multiple candidate schizophrenia susceptibility genes whose functions converge on the glutamatergic neurotransmitter system. One such susceptibility gene encoding D-amino acid oxidase (DAO), an enzyme that metabolizes the NMDA receptor (NMDAR) co-agonist D-serine, has the potential to modulate NMDAR function in the ... [more]
J. Biol. Chem. Aug. 19, 2011; 286(33);28867-75 [Pubmed: 21700703]
Throughput
- Low Throughput
Curated By
- BioGRID